Table 1 Baseline characteristics and incident cancer cases during follow-up included men and women
Characteristic | Men (n = 158,334) | Women (n = 174,083) | P-value |
|---|---|---|---|
Baseline characteristics N (%) | |||
Age (years) | 58 (50, 63) | 57 (49, 63) | < 0.001 |
Ethnicity | 0.194 | ||
White | 150,447 (95.0%) | 165,240 (94.9%) | |
Others | 7887 (5.0%) | 8,843 (5.1%) | |
Education levels | < 0.001 | ||
1 | 24,405 (15.4%) | 26,408 (15.2%) | |
2 | 38,303 (24.2%) | 50,241 (28.9%) | |
3 | 16,963 (10.7%) | 21,472 (12.3%) | |
4 | 7,013 (4.4%) | 9,939 (5.7%) | |
5 | 70,396 (44.5%) | 64,663 (37.1%) | |
Unknown | 1,254 (0.8%) | 1,360 (0.8%) | |
Annual household income before tax, £ | < 0.001 | ||
< 18,000 | 27,118 (17.1%) | 33,904 (19.5%) | |
18,000–30,999 | 34,061 (21.5%) | 38,120 (21.9%) | |
31 000–51,999 | 39,389 (24.9%) | 38,442 (22.1%) | |
52,000-100,000 | 33,870 (21.4%) | 29,126 (16.7%) | |
> 100,000 | 9,422 (6.0%) | 7,684 (4.4%) | |
Unknown /Not prefer to answer | 14,474 (9.1%) | 26,807 (15.4%) | |
Townsend deprivation index | -2.2 (-3.7,0.4) | -2.2 (-3.7,0.3) | 0.417 |
Alcohol status | < 0.001 | ||
Never | 3,935 (2.5%) | 9,403 (5.4%) | |
Previous | 5,303 (3.3%) | 5,997 (3.4%) | |
Current | 148,997 (94.1%) | 158,585 (91.1%) | |
Prefer not to answer | 99 (0.1%) | 98 (0.1%) | |
Menopause | NA | ||
Yes | 103,382 (59.4%) | ||
No | 44,308 (25.5%) | ||
Unknown | 26,393 (15.2%) | ||
CVD | 16,273 (10.3%) | 8,625 (5.0%) | < 0.001 |
AHA Life’s Essential 8 score | |||
Total CVH score | 64.4 (55.6,72.5) | 70 (61.2, 78.1) | < 0.001 |
Diet score | 50 (25, 80) | 50 (25, 80) | < 0.001 |
Blood pressure score | 25 (5, 50) | 50 (25, 75) | < 0.001 |
Blood glucose score | 100 (100, 100) | 100 (100, 100) | < 0.001 |
Sleep health score | 100 (70, 100) | 100 (70, 100) | < 0.001 |
Body mass index score | 70 (30, 70) | 70 (70, 100) | < 0.001 |
Physical activity score | 100 (100, 100) | 100 (90, 100) | < 0.001 |
Tobacco/nicotine exposure score | 50 (25, 100) | 75 (25, 100) | < 0.001 |
Blood lipid score | 40 (20, 60) | 40 (20, 60) | < 0.001 |
Cancer types and subtypes [Incident cases, (%)] | |||
Overall cancer | 27,706 (17.5%) | 23,121 (13.3%) | < 0.001 |
Anus | 49 (0.0%) | 77 (0.0%) | 0.049 |
Bladder | 513 (0.3%) | 170 (0.1%) | < 0.001 |
Brain | 297 (0.2%) | 216 (0.1%) | < 0.001 |
Breast | 44 (0.0%) | 6,114 (3.5%) | < 0.001 |
Colorectal | 2,212 (1.4%) | 1,644 (0.9%) | < 0.001 |
Esophageal | 469 (0.3%) | 175 (0.1%) | < 0.001 |
Esophageal adenocarcinoma (EAC) | 351 (0.2%) | 66 (0.0%) | < 0.001 |
Esophageal squamous cell carcinoma (ESCC) | 74 (0.0%) | 93 (0.1%) | 0.39 |
Kidney | 614 (0.4%) | 313 (0.2%) | < 0.001 |
Renal cell carcinoma (RCC) | 529 (0.3%) | 272 (0.2%) | < 0.001 |
Transitional cell carcinoma (TCC) | 40 (0.0%) | 19 (0.0%) | 0.002 |
Laryngeal | 115 (0.1%) | 5 (0.0%) | < 0.001 |
Leukemia | 495 (0.3%) | 315 (0.2%) | < 0.001 |
Liver | 289 (0.2%) | 130 (0.1%) | < 0.001 |
Hepatocellular carcinoma (HCC) | 176 (0.1%) | 27 (0.0%) | < 0.001 |
Cholangiocarcinoma (CAC) | 92 (0.1%) | 95 (0.1%) | 0.668 |
Lung | 1,350 (0.9%) | 1,205 (0.7%) | < 0.001 |
Small cell carcinoma (SCLC) | 163 (0.1%) | 176 (0.1%) | 0.868 |
Non-small cell carcinoma (NSCLC) | 982 (0.6%) | 894 (0.5%) | 0.325 |
Lymphoma | 826 (0.5%) | 677 (0.4%) | < 0.001 |
Hodgkin’s lymphoma (HL) | 52 (0.0%) | 42 (0.0%) | 0.136 |
Non-Hodgkin’s lymphoma (NHL) | 743 (0.5%) | 602 (0.3%) | < 0.001 |
Mesothelioma | 208 (0.1%) | 52 (0.0%) | < 0.001 |
Multiple Myeloma | 352 (0.2%) | 245 (0.1%) | < 0.001 |
Oral | 435 (0.3%) | 223 (0.1%) | < 0.001 |
Ovarian | NA | 637 (0.4%) | |
Pancreatic | 462 (0.3%) | 381 (0.2%) | < 0.001 |
Prostate | 7,725 (4.9%) | NA | |
Melanoma skin | 10,018 (6.3%) | 8,280 (4.8%) | < 0.001 |
Small intestine | 87 (0.1%) | 78 (0.0%) | 0.19 |
Soft tissue | 115 (0.1%) | 168 (0.1%) | 0.018 |
Stomach | 319 (0.2%) | 143 (0.1%) | < 0.001 |
Thyroid | 81 (0.1%) | 211 (0.1%) | < 0.001 |
Uterine | NA | 1,003 (0.6%) |