Fig. 2

The analysis of protein expression and related signaling pathways in different groups. (A) Relationship between total T1 and T2 expression and proportion of immune cells. (B) Relationship between expression and proportion of immune cells in T1 and T2 groups before and after treatment. (C) WGCNA results show the gene modules in distinct treatment response phenotype. Columns represent treatment response phenotype. The color change from blue to red indicates a low to high correlation between gene module and cell subtypes (Pearson’s correlation test). (D) Dot plot showing the GO enrichment analysis results using the hub genes in different response groups. Colors from blue to red indicate the Log10(P-value + 1) low to high (clusterProfiler). (E) GO enrichment analysis based on the background of 92 inflammation-related proteins. BF: Before Treatment, AF: After Treatment