Table 2 Forty-two common gene targets of individual members of miR- 23a/24–2/27a cluster and their function in cancer

NEK6

NIMA related kinase 6

Regulates cancer cell invasion and metastasis

[23]

NR6A1

Nuclear Receptor Subfamily 6, Group A, Member 1

Overexpressed in prostate cancer cases

[24]

ZNF395

Zinc finger protein 395

It promotes progression of cancer

[25]

SOCS6

Suppressor of cytokine signalling 6

It is downregulated in various carcinomas

[26]

EBF3

EBF Transcription factor 3

They regulate developmental pathways including B cell differentiation, and development of bone

[27]

MEIS2

Meis Homeobox 2

It is involved in ontogeny and differentiation as well as organ development

[28]

DCUN1D5

Defective In Cullin Neddylation 1 Domain Containing 5

Play a role in DNA damage response to genotoxic stress

[29]

PLEKHH2

Pleckstrin Homology, MyTH4 and FERM Domain Containing H2

Promotes the malignancy of non-small cell lung cancer

[30]

HIC1

HIC ZBTB Transcriptional Repressor 1

It is a tumor suppressor

[31]

NCOA1

Nuclear Receptor Coactivator 1

Promotes metastasis of breast cancer

[32]

CELF2

CUGBP, Elav-like family member 2

It negatively regulates breast cancer cell invasion

[33]

NFIB

Nuclear Factor I/B

Promotes angiogenesis at the site of metastasis

[34]

RAP1B

Ras associated protein 1

Promotes invasiveness and tumorigenicity of breast cancer

[35]

C17orf85

Nuclear Cap Binding protein 3

Also called NCPB3, it is an mRNA protein

[36]

REPS2

RALBP1 associated Eps domain containing 2

Dysregulated during prostate cancer progression

[37]

GSK3β

Glycogen Synthase Kinase 3 Beta

It negatively regulates breast cancer tumorigenicity

[37]

SMAD5

SMAD family member 5

It induces chemoresistance in breast cancer

[38]

CBX5

Chromobox 5

It functions as an oncogene

[39]

UBN2

Ubinuclein 2

It promotes tumor progression in colorectal cancer

[40]

KPNA3

Karyopherin subunit alpha 3

It positively regulates EMT in triple negative breast cancer

[41]

CSNK1G1

casein kinase 1 gamma 1

It is overexpressed in triple negative breast cancer

[42]

MBD5

methyl-CpG-binding domain (MBD) 5

It promotes tumor cell growth

[43]

STRN

Striatin

It forms signalling hubs with different kinases and phosphatases and other signalling proteins called STRIPAK

[44]

CLCN3

Chloride Channel 3

It prevents proliferation of ovarian cancer cells

[45]

RSBN1L

Round Spermatid Basic Protein 1 Like

Its overexpression is involved with better prognosis of breast cancer

[46]

PLAG1

Pleomorphic adenoma gene 1

It promotes cell proliferation in various cancers

[47]

DTNA

Dystrobrevin Alpha

It is involved in cardiovascular malignancies

[47]

ADAM19

A disintegrin and metalloproteinase 19

It is overexpressed in breast invasive carcinoma

[48]

SHROOM2

Shroom family member 2

It plays a role in EMT and cancer cell metastasis inhibition

[49]

LIMK2

LIM domain Kinase 2

It is overexpressed in triple negative breast cancer

[50]

MIDN

Midnolin

Involved in kinase binding and plays a role in Parkinson’s Disease

[51]

TAOK1

Thousand and one amino acid kinase 1

It promotes proliferation and invasion of non-small cell lung cancer

[52]

PDE3A

Phosphodiesterase 3 A

It is upregulated in breast cancer

[53]

WDFY2

WD repeat and FYVE domain-containing protein 2

It is a tumor suppressor gene

[54]

NLK

Nemo like kinase

It is involved in cancer cell cycle progression and tumorigenesis

[55]

IPMK

Inositol Polyphosphate Multikinase

It has tumor -suppressive role

[56]

SP1

Specificity Protein 1

Overexpressed in numerous cancer

[57]

NRP2

Neuropilin 2

Associated with poor prognosis in breast cancer

[58]

PURA

Purine Rich Element Binding Protein A

Overexpressed in tumor

[59]

BNIP3L

BCL2 Interacting Protein 3 Like

Upregulated expression in breast cancer

[60]

UBE2K

Ubiquitin Conjugating Enzyme E2 K

It promotes tumor malignancies

[61]

WISP1

WNT1 Inducible Signaling Pathway Protein 1

It positively regulates cancer cell progression and metastasis

[62]