Variables | Sensitivity | Specificity | PPV | NPV | Accuracy | Sensitivity (Stage I) | Sensitivity (< 3 cm) |
|---|
GPC3 | 76.92% | 73.08% | 74.07% | 76.00% | 50.00%a | 86.49%c | 72.41%e |
PIVKA-II | 84.62% | 90.38% | 89.80% | 85.45% | 75.00%b | 83.78%d | 79.31%f |
Nomogram | 95.20% | 81.70% | 83.90% | 94.40% | 76.90% | 94.60% | 93.10% |
P value | 0.001 | 0.008 | 0.010 | 0.002 | 0.000 | 0.036 | 0.001 |
- GPC3, detectable serum GPC3, at a cut-off value of 0.100 ng/mL
- PIVKA-II, detectable serum PIVKA-II, at a cut-off value of 40.00 mAU/mL
- Nomogram, the scores of the variables including GPC3 (score: 0 = 0, 1 = 36), PIVKA-II (score: 0 = 0, 1 = 100), and GGT (score: 0 = 0, 1 = 56) were calculated, followed by determining the positions of eachvariable on the related axis. Vertical lines were then drawn on each axis, and the corresponding scores were found. Each variable’s score was further added to obtain the total score, at a cut-off value of 73.338
- PPV, positive predictive value; NPV, negative predictive value
- Three variables were compared by the chi-square test or Fisher’s exact test and P < 0.05 was statistically significant.a: Nomogram vs. GPC3 in accuracy, P = 0.000
- b: Nomogram vs. PIVKA-II in accuracy, P = 0.741
- c: Nomogram vs. GPC3 in sensitivity (Stage I), P = 0.030
- d: Nomogram vs. PIVKA-II in sensitivity (Stage I), P = 0.011
- e: Nomogram vs. GPC3 in sensitivity (< 3 cm), P = 0.000
- f: Nomogram vs. PIVKA-II in sensitivity (< 3 cm), P = 0.003
