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Table 2 Basic demographic and clinical data of patients with N-BLD and N-HCC

From: Diagnostic and prognostic performance of serum GPC3 and PIVKA-II in AFP-negative hepatocellular carcinoma and establishment of nomogram prediction models

Clinical features

N-BLD(n = 104)

N-HCC(n = 104)

OR(95%CI)

P value

Cirrhosis, n(%)

69 (66.35%)

70 (67.31%)

0.958 (0.538–1.706)

0.883

CHB, n(%)

35 (33.65%)

27 (25.96%)

1.447 (0.796–2.631)

0.225

Age ≤ 60years, n(%)

53 (50.96%)

52 (50.00%)

1.039 (0.603–1.790)

0.890

Male, n(%)

96 (92.31%)

96 (92.31%)

1.000 (0.361–2.733)

1.000

Hepatitis B virus, n(%)

94 (90.38%)

92 (88.46%)

1.226 (0.505–2.977)

0.652

Child- Pugh class A, n(%)

45 (43.27%)

45 (43.27%)

1.000 (0.578–1.731)

1.000

Child- Pugh class B, n(%)

53 (50.96%)

54 (51.92%)

0.962 (0.559–1.658)

0.890

ALB < 40 g/L, n(%)

40 (38.46%)

69 (66.35%)

0.317 (0.180–0.559)

0.000

TBIL > 21µmol/L, n(%)

41 (39.42%)

30 (28.85%)

1.605 (0.900-2.863)

0.108

ALT > ULN, n(%)

18 (17.31%)

33 (31.73%)

0.450 (0.234–0.867)

0.016

AST > ULN, n(%)

34 (32.69%)

51 (49.04%)

0.505 (0.288–0.885)

0.016

ALP > ULN, n(%)

25 (24.04%)

42 (40.38%)

0.467 (0.257–0.848)

0.012

GGT > ULN, n(%)

37 (35.58%)

79 (75.96%)

0.175 (0.096–0.319)

0.000

  1. N-BLD, AFP-negative benign liver disease (AFP < 20 ng/mL). N-HCC, AFP-negative hepatic celluler cancer (AFP < 20 ng/mL). CHB, Chronic Hepatitis B. ALB, albumin. TBIL, total bilirubin. ULN, upper limit of normal. ALT, aminoleucine transferase, ULN (male) = 50 µmol/L, ULN (female) = 40 µmol/L. AST, Aspartate aminotransferase, ULN (male) = 40 µmol/L, ULN (female) = 35 µmol/L. ALP, Alkaline Phosphatase, ULN (male) = 125 U/L, ULN (female) = 135 U/L. GGT, Gamma-glutamyltransferase, ULN (male) = 60 U/L, ULN (female) = 45 U/L
  2. N-BLD vs. N-HCC, were compared by the chi-square test or Fisher’s exact test, and P < 0.05 was statistically significant