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Table 1 Basic demographic and clinical data of 411 patients with HCC

From: Diagnostic and prognostic performance of serum GPC3 and PIVKA-II in AFP-negative hepatocellular carcinoma and establishment of nomogram prediction models

Clinical features

HCC(n = 411)

N-HCC(n = 104)

A-HCC (n = 307)

OR (95%CI)

P value

Age, n(%)

     

 ≤ 60years

266 (64.72%)

52 (50.00%)

214 (69.71%)

301 (1.460–3.627)

0.000

 > 60years

145 (35.28%)

52 (50.00%)

93 (30.29%)

Gender, n(%)

     

 Male

356 (86.62%)

96 (92.31%)

260 (84.69%)

0.461 (0.210–1.011)

0.049

 Female

55 (13.38%)

8 (7.69%)

47 (15.31%)

Cirrhosis, n(%)

     

 Yes

267 (64.96%)

70 (67.31%)

197 (64.17%)

0.870 (0.543–1.394)

0.562

 No

144 (35.04%)

34 (32.69%)

110 (35.83%)

TNM stage, n(%)

     

 Stage I

76 (18.49%)

37 (35.58%)

39 (12.70%)

0.496 (0.389–0.633)

0.000

 Stage II

75 (18.25%)

27 (25.96%)

48 (15.64%)

 Stage III

199 (48.42%)

30 (28.85%)

169 (55.05%)

 Stage IV

61 (14.84%)

10 (9.61%)

51 (16.61%)

Tumor size, n(%)

     

 < 3 cm

59 (14.36%)

29 (27.89%)

30 (9.77%)

0.391 (0.289–0.530)

0.000

 3–5 cm

116 (28.22%)

42 (40.38%)

74 (24.11%)

 > 5 cm

236 (57.42%)

33 (31.73%)

203 (66.12%)

Daughter nodule, n(%)

     

 Yes

216 (52.55%)

49 (47.12%)

167 (54.40%)

0.747 (0.478–1.166)

0.199

 No

195 (47.45%)

55 (52.88%)

140 (45.60%)

Intrahepatic metastasis, n(%)

     

 Yes

209 (50.85%)

34 (32.69%)

175 (57.00%)

2.730 (1.710–4.358)

0.000

 No

202 (49.15%)

70 (67.31%)

132 (43.00%)

Distant metastasis, n(%)

     

 Yes

114 (27.74%)

21(20.19%)

93 (30.29%)

1.718 (1.004–2.939)

0.047

 No

297 (72.26%)

83(79.81%)

214 (69.71%)

  1. HCC, hepatic celluler cancer. N-HCC, AFP-negative hepatic celluler cancer (AFP < 20 ng/mL). A-HCC, AFP-positive hepatic cellular cancer (AFP ≥ 20 ng/mL). N-HCC vs. A-HCC, were compared by the chi-square test or Fisher’s exact test and P < 0.05 was statistically significant