Table 9 The multiplicative interaction between SNPs, smoking and AN chewing

rs17486278

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

2.212 (0.334 ~ 21.968)

0.436

3.095 (0.381 ~ 39.740)

0.335

Yes

No

1.064 (0.693 ~ 1.638)

0.779

1.102 (0.711 ~ 1.716)

0.664

Yes

Yes

1.602 (0.659 ~ 4.214)

0.313

1.573 (0.640 ~ 4.176)

0.338

rs555018

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

4.964 (0.398 ~ 132.289)

0.245

5.985 (0.403 ~ 176.232)

0.220

Yes

No

0.908 (0.531 ~ 1.566)

0.727

0.897 (0.515 ~ 1.574)

0.703

Yes

Yes

4.964 (0.706 ~ 100.947)

0.164

4.747 (0.656 ~ 97.724)

0.180

rs692780

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

4.334 (0.348 ~ 115.498)

0.288

5.218 (0.352 ~ 153.561)

0.257

Yes

No

0.714 (0.418 ~ 1.223)

0.217

0.705 (0.406 ~ 1.228)

0.215

Yes

Yes

4.334 (0.617 ~ 88.134)

0.202

4.142 (0.573 ~ 85.271)

0.221

rs3743078

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

2.199 (0.348 ~ 21.583)

0.430

2.661 (0.341 ~ 34.784)

0.403

Yes

No

0.938 (0.573 ~ 1.542)

0.799

0.930 (0.560 ~ 1.551)

0.780

Yes

Yes

1.853 (0.561 ~ 7.554)

0.341

1.849 (0.547 ~ 7.729)

0.352

rs1317286

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

0.859 (0.028 ~ 26.638)

0.923

0.815 (0.022 ~ 30.173)

0.904

Yes

No

0.767 (0.421 ~ 1.406)

0.386

0.813 (0.441 ~ 1.511)

0.509

Yes

Yes

1.197 (0.323 ~ 5.161)

0.794

1.207 (0.318 ~ 5.383)

0.790

rs938682

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

0.247 (0.013 ~ 1.564)

0.205

0.185 (0.009 ~ 1.341)

0.147

Yes

No

1.241 (0.825 ~ 1.872)

0.301

1.209 (0.796 ~ 1.840)

0.374

Yes

Yes

0.539 (0.199 ~ 1.331)

0.195

0.568 (0.208 ~ 1.422)

0.243

rs7178270

No

No

1.000 (ref.)

1.000 (ref.)

No

Yes

6.998 (0.758 ~ 188.076)

0.145

8.104 (0.885 ~ 220.071)

0.114

Yes

No

0.898 (0.601 ~ 1.343)

0.598

0.900 (0.596 ~ 1.360)

0.616

Yes

Yes

2.293 (0.835 ~ 7.366)

0.130

2.476 (0.871 ~ 8.312)

0.110