Table 5 The multiplicative interaction between SNPs and smoking

rs17486278

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

1.092 (0.725 ~ 1.651)

0.676

1.122 (0.737 ~ 1.713)

0.593

AA

No

1.000 (ref.)

1.000 (ref.)

AC

No

1.276 (0.859 ~ 1.896)

0.227

1.351 (0.893 ~ 2.047)

0.155

CC

No

1.152 (0.593 ~ 2.195)

0.669

1.096 (0.552 ~ 2.137)

0.790

AA

Yes

2.844 (1.921 ~ 4.240)

 < 0.001

5.238 (3.256 ~ 8.560)

 < 0.001

AC

Yes

2.689 (1.809 ~ 4.023)

 < 0.001

5.106 (3.153 ~ 8.396)

 < 0.001

CC

Yes

6.454 (3.152 ~ 14.353)

 < 0.001

12.548 (5.776 ~ 29.401)

 < 0.001

rs555018

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

0.949 (0.561 ~ 1.619)

0.846

0.931 (0.541 ~ 1.615)

0.798

AA

No

1.000 (ref.)

1.000 (ref.)

AG

No

1.163 (0.749 ~ 1.796)

0.498

1.153 (0.728 ~ 1.818)

0.541

GG

No

0.730 (0.195 ~ 2.292)

0.607

0.683 (0.175 ~ 2.259)

0.548

AA

Yes

2.801 (2.043 ~ 3.857)

 < 0.001

5.127 (3.421 ~ 7.795)

 < 0.001

AG

Yes

2.485 (1.588 ~ 3.923)

 < 0.001

4.391 (2.631 ~ 7.437)

 < 0.001

GG

Yes

4.382 (1.243 ~ 20.281)

0.031

7.540 (2.010 ~ 36.307)

0.005

rs692780

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

0.753 (0.446 ~ 1.276)

0.289

0.738 (0.430 ~ 1.270)

0.271

GG

No

1.000 (ref.)

1.000 (ref.)

CG

No

1.348 (0.876 ~ 2.067)

0.172

1.313 (0.838 ~ 2.053)

0.232

CC

No

0.859 (0.225 ~ 2.785)

0.807

0.847 (0.212 ~ 2.928)

0.799

GG

Yes

3.026 (2.196 ~ 4.190)

 < 0.001

5.553 (3.685 ~ 8.490)

 < 0.001

CG

Yes

2.449 (1.592 ~ 3.795)

 < 0.001

4.227 (2.570 ~ 7.051)

 < 0.001

CC

Yes

4.008 (1.093 ~ 18.854)

0.047

7.586 (1.970 ~ 36.898)

0.005

rs3743078

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

0.967 (0.601 ~ 1.563)

0.890

0.956 (0.585 ~ 1.568)

0.858

CC

No

1.000 (ref.)

1.000 (ref.)

CG

No

1.203 (0.809 ~ 1.784)

0.360

1.192 (0.787 ~ 1.802)

0.405

GG

No

0.847 (0.258 ~ 2.451)

0.768

0.863 (0.253 ~ 2.630)

0.802

CC

Yes

2.718 (1.931 ~ 3.844)

 < 0.001

4.952 (3.236 ~ 7.684)

 < 0.001

CG

Yes

3.118 (2.060 ~ 4.763)

 < 0.001

5.458 (3.366 ~ 8.991)

 < 0.001

GG

Yes

2.542 (1.019 ~ 6.673)

0.048

4.812 (1.821 ~ 13.331)

0.002

rs1317286

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

0.809 (0.454 ~ 1.452)

0.474

0.855 (0.473 ~ 1.555)

0.604

AA

No

1.000 (ref.)

1.000 (ref.)

AG

No

0.998 (0.619 ~ 1.592)

0.995

0.998 (0.607 ~ 1.625)

0.994

GG

No

2.710 (0.655 ~ 13.377)

0.177

2.473 (0.581 ~ 12.497)

0.229

AA

Yes

2.795 (2.058 ~ 3.811)

 < 0.001

5.027 (3.377 ~ 7.594)

 < 0.001

AG

Yes

2.394 (1.497 ~ 3.865)

 < 0.001

4.528 (2.633 ~ 7.898)

 < 0.001

GG

Yes

4.065 (0.863 ~ 28.651)

0.096

7.863 (1.597 ~ 57.173)

0.017

rs938682

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

1.166 (0.787 ~ 1.731)

0.444

1.151 (0.770 ~ 1.724)

0.493

AA

No

1.000 (ref.)

1.000 (ref.)

AG

No

1.020 (0.662 ~ 1.578)

0.928

1.137 (0.723 ~ 1.798)

0.580

GG

No

0.577 (0.324 ~ 1.011)

0.057

0.559 (0.307 ~ 1.004)

0.054

AA

Yes

2.482 (1.513 ~ 4.111)

 < 0.001

5.061 (2.845 ~ 9.152)

 < 0.001

AG

Yes

2.570 (1.650 ~ 4.035)

 < 0.001

4.836 (2.854 ~ 8.327)

 < 0.001

GG

Yes

2.025 (1.152 ~ 3.594)

0.015

4.080 (2.159 ~ 7.827)

 < 0.001

rs7178270

SNP

No

1.000 (ref.)

1.000 (ref.)

SNP

Yes

0.947 (0.641 ~ 1.400)

0.785

0.948 (0.635 ~ 1.417)

0.794

CC

No

1.000 (ref.)

1.000 (ref.)

CG

No

1.380 (0.910 ~ 2.104)

0.132

1.378 (0.892 ~ 2.139)

0.150

GG

No

1.791 (1.021 ~ 3.146)

0.042

1.775 (0.988 ~ 3.192)

0.054

CC

Yes

2.921 (1.863 ~ 4.623)

 < 0.001

5.299 (3.140 ~ 9.092)

 < 0.001

CG

Yes

3.434 (2.236 ~ 5.325)

 < 0.001

6.161 (3.724 ~ 10.374)

 < 0.001

GG

Yes

4.950 (2.770 ~ 9.092)

 < 0.001

8.967 (4.720 ~ 17.555)

 < 0.001