Table 4 Analyses of the association between variations in MIR17HG promoter and cancers risk
Polymorphisms | Â | Effect size | Heterogeneity | Â | ||
|---|---|---|---|---|---|---|
Gene Model | OR (95% CI) | p-value | I2 (%) | p-value | Effect model | |
rs9588884 C> G | Allelic model (G vs. C) | 0.77 (0.71, 0.84) | 0.000 | 33.20% | 0.213 | Fixed |
Dominant model (CGGG vs. CC) | 0.75 (0.66, 0.85) | 0.000 | 0.00% | 0.563 | Fixed | |
Recessive model (GG vs. CCCG) | 0.62 (0.53, 0.74) | 0.000 | 50.00% | 0.112 | Fixed | |
Homozygous model (GG vs. CC) | 0.55 (0.46, 0.67) | 0.000 | 51.90% | 0.101 | Random | |
Heterozygous model (CG vs. CC) | 0.83 (0.72, 0.94) | 0.005 | 0.00% | 0.850 | Fixed | |
rs982873 T> C | Allelic model (C vs. T) | 0.87 (0.77, 0.98) | 0.027 | 50.10% | 0.111 | Random |
Dominant model (TCCC vs. TT) | 0.87 (0.77, 0.99) | 0.040 | 0.00% | 0.410 | Fixed | |
Recessive model (CC vs. TTTC) | 0.74 (0.56, 0.99) | 0.039 | 63.40% | 0.042 | Random | |
Homozygous model (CC vs. TT) | 0.71 (0.52, 0.97) | 0.032 | 62.10% | 0.048 | Random | |
Heterozygous model (TC vs. TT) | 0.94 (0.82, 1.08) | 0.370 | 0.00% | 0.673 | Fixed | |
rs1813389 A> G | Allelic model (G vs. A) | 0.95 (0.86, 1.04) | 0.283 | 14.60% | 0.310 | Fixed |
Dominant model (AGGG vs. AA) | 0.97 (0.84, 1.11) | 0.629 | 0.00% | 0.588 | Fixed | |
Recessive model (GG vs. AAAG) | 0.88 (0.73, 1.05) | 0.156 | 30.80% | 0.236 | Fixed | |
Homozygous model (GG vs. AA) | 0.88 (0.72, 1.07) | 0.191 | 31.50% | 0.232 | Fixed | |
Heterozygous model (AG vs. AA) | 0.99 (0.86, 1.15) | 0.944 | 0.00% | 0.806 | Fixed | |