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Table 4 Patient characteristics and sample conditions in this study (n = 478)

From: Real-world application of targeted next-generation sequencing for identifying molecular variants in Asian non-small-cell lung cancer

 

Total

NGS Success Group

NGS Failure Group

p-value

No

(%)

No

(%)

No

(%)

 

Number of cases

478

100.0

385

80.5

93

19.5

 

Age

      

0.965

 Median

64

64

65

 

 Range

30–96

30–96

33–96

 

Sex

      

0.913

 Male

234

49.0

188

48.8

46

49.5

 

 Female

244

51.0

197

51.2

47

50.5

 

Tumor%

      

 < 0.0001*

 Median

40

40

20

 

 Range

1–90

10–90

1–80

 

Specimen source

      

 < 0.0001*

 Biopsy

310

64.9

226

58.7

84

90.3

 

 Cytology

43

9.0

37

9.6

6

6.5

 

 Surgical resection

125

26.2

122

31.7

3

3.2

 

FFPE block age

      

 < 0.0001*

 < 1 year

407

85.1

345

89.6

62

66.7

 

 1–2 years

53

11.1

28

7.3

25

26.9

 

 2–3 years

10

2.1

7

1.8

3

3.2

 

 > 3 years

8

1.7

5

1.3

3

3.2

 

Biopsy sampling method

      

0.127

 Bronchoscopic biopsy

55

17.7

42

18.6

13

15.5

 

 CT-guided biopsy

123

39.7

83

36.7

40

47.6

 

 EBUS biopsy

24

7.7

18

8.0

6

7.1

 

 Endoscopic biopsy

3

1.0

3

1.3

0

0.0

 

 Excisional biopsy

7

2.3

6

2.7

1

1.2

 

 Needle biopsy

44

14.2

28

12.4

16

19.0

 

 Sonography-guided biopsy

54

17.4

46

20.4

8

9.5

 

Anatomic site

      

0.203

 Primary tumor

289

60.5

231

60.0

58

62.4

 

 Metastatic tumor (CNS)

24

5.0

23

6.0

1

1.1

 

 Metastatic tumor (Lymph Node)

36

7.5

28

7.3

8

8.6

 

 Metastatic tumor (Bone)

25

5.2

21

5.5

4

4.3

 

 Metastatic tumor (Colon)

3

0.6

3

0.8

0

0.0

 

 Metastatic tumor (Liver)

22

4.6

14

3.6

8

8.6

 

 Metastatic tumor (Others)

36

7.5

28

7.3

8

8.6

 

 Cytology

43

9.0

37

9.6

6

6.5

 
  1. *p < 0.05