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Table 4 Related factors of HCC occurring 9–16 years after SVS

From: Analysis of high-risk factors for hepatocellular carcinoma after sustained virological suppression of chronic hepatitis B

 

Univariate

 

Multivariate

 

Factors

HR

95%CI

p-value

HR

95%CI

p-value

Sex(male,%)

      

 Female

1

     

 Male

3.853

(1.531–9.697)

0.00400

4.396

(1.73-11.166)

0.0020

Age(years)

      

 <40

1

     

 ≥40

6.366

(2.716–14.92)

< 0.0001

4.018

(1.637–9.864)

0.0020

Hypertension

      

 Absence

1

     

 Presence

1.067

(0.547–2.081)

0.849

0.461

(0.216–0.983)

0.0450

DM

      

 Absence

1

     

 Presence

2.977

(1.626–5.449)

< 0.0001

2.464

(1.254–4.843)

0.0090

Dyslipidaemia

      

 Absence

1

     

 Presence

0.558

(0.173–1.792)

0.327

0.474

(0.144–1.559)

0.2190

BMI (kg/m2)

      

 <25

1

     

 ≥25

1.416

(0.775–2.586)

0.258

1.193

(0.638–2.231)

0.5800

γGT (U/L)

      

 <56

1

     

 ≥56

1.650

(0.951–2.864)

0.0750

0.925

(0.508–1.686)

0.8000

FIB-4 score

      

 ≤ 3.25

1

     

 >3.25

4.541

(2.556–8.069)

< 0.0001

2.676

(1.354–5.288)

0.0050

APRI score

      

 <2

1

     

 ≥2

1.979

(1.113–3.520)

0.0200

0.829

(0.411–1.674)

0.6020

ALBI score

      

 <-2.60)

1

     

 ≥-2.60

2.470

(1.325–4.604)

0.00400

1.574

(0.784–3.16)

0.2020

eGFR (mL/min/1.73 m2)

      

 ≥60

1

     

 <60

1.292

(0.581–2.872)

0.530

1.365

(0.582-3.2)

0.4750

AFP (ng/ml)

      

 <5.0

1

     

 ≥5.0

3.094

(1.769–5.411)

< 0.0001

2.492

(1.309–4.745)

0.0050

HBeAg

      

 Absence

1

     

 Presence

0.602

(0.336–1.078)

0.0880

0.549

(0.294–1.023)

0.0590