Table 3 Grade 3 or worse adverse events
Combination therapy (N = 100) | Monotherapy (N = 57) | p-value‡ | |||
|---|---|---|---|---|---|
n | (%) | n | (%) | ||
Total | 79 | (79) | 30 | (53) | 0.001 |
Hematological adverse event | 70 | (70) | 25 | (44) | 0.002 |
Neutropenia | 77 | (77) | 17 | (30) | < 0.001 |
Thrombocytopenia | 18 | (18) | 10 | (18) | 1.000 |
Anemia | 14 | (14) | 5 | (9) | 0.287 |
Nonhematological adverse event | 23 | (23) | 8 | (14) | 0.214 |
Cardiac disorders | 4 | (4.0) | 3 | (5.3) | 0.354 |
Anorexia | 2 | (2.0) | 3 | (5.3) | 0.354 |
Sepsis | 1 | (1.0) | 3 | (5.3) | 0.136 |
Skin rash | 5 | (5.0) | 0 | (0) | 0.160 |
Interstitial pneumonia | 3 | (3.0) | 0 | (0) | 0.554 |
Renal dysfunction | 1 | (1.0) | 0 | (0) | 1.000 |
Fatigue | 1 | (1.0) | 0 | (0) | 1.000 |
Peripheral sensory neuropathy | 1 | (1.0) | 0 | (0) | 1.000 |
Oral mucositis | 1 | (1.0) | 0 | (0) | 1.000 |
Febrile neutropenia | 1 | (1.0) | 0 | (0) | 1.000 |
Others | 3 | (3.0) | 0 | (0) | 0.554 |