Table 1 Patients’ characteristics

Age, years, median (range)

78

(75–86)

81

(75–90)

< 0.001^†

Sex, Female, n (%)

33

(33)

21

(37)

0.626^‡

BMI (kg/m²), median (range)

21.9

(14.1–35.7)

21.4

(13.4–28.8)

0.18^‡

ECOG PS, n (%)

 0

 1

 2

73

25

2

(73)

(25)

(2)

32

17

8

(56)

(30)

(14)

0.007^‡

Primary tumor sites, n (%)

 Ampulla

 Gallbladder

 Intrahepatic bile duct

 Extrahepatic bile duct

8

23

26

43

(8)

(23)

(26)

(43)

2

18

14

23

(4)

(32)

(25)

(39)

0.503^‡

Disease stage, n (%)

 Unresectable

 Recurrence

84

16

(84)

(16)

47

10

(82)

(18)

0.062^‡

NLR, median (range)

2.46

(0.86–23.6)

2.82

(0.75–21.7)

0.32^†

Albumin (g/dL), median (range)

3.6

(2.0–4.4)

3.4

(2.2–4.7)

0.005^†

CRP (mg/dL), median (range)

0.53

(0.03–9.53)

0.95

(0.02–11.28)

0.226^†

CEA (ng/mL), median (range)

3.0

(0.9–588.3)

4.6

(1.0–418)

0.033^†

CA 19 − 9 (U/mL), median (range)

96.3

(2–1126400)

4337

(2–1628200)

0.366^†

Biliary drainage, n (%)

55

(55)

30

(53)

0.774^‡

Second-line chemotherapy, n (%)

55

(55)

24

(42)

0.119^‡