Fig. 8

ITGB3 knockdown inhibited the proliferation and migration of chordoma cells in vitro. (A) Volcano map showed DEGs between ITGB3 high and low expression groups. (B) KEGG analysis of up-regulated genes in ITGB3 high expression group. (C-D) qRT-PCR validation in chordoma cells with or without ITGB3 knockdown. (E) The protein expression of ITGB3 and AKT in chordoma cells with or without ITGB3 knockdown. (F-G) CCK8 results of chordoma cells with or without ITGB3. (H-I) The migration cells were significantly reduced in chordoma cells with ITGB3 knockdown. (J-K) The number of cell colonies significantly decreased in chordoma cells with ITGB3 knockdown. *, p-value < 0.05; **, p-value < 0.01