Table 1 Characteristics for all patients from primary and external cohorts
Characteristic | Training cohort (n = 128) | P | Validation cohort (n = 64) | P | Test cohort (n = 30) | P | |||
|---|---|---|---|---|---|---|---|---|---|
NAT-low (n = 70) | NAT-high (n = 58) | NAT-low (n = 35) | NAT-high (n = 29) | NAT-low (n = 16) | NAT-high (n = 14) | ||||
Age, year (Mean ± SD) | 51.34 ± 10.92 | 53.03 ± 10.17 | 0.488 | 53.59 ± 8.95 | 51.26 ± 10.66 | 0.206 | 47.41 ± 8.93 | 48.50 ± 9.44 | 0.892 |
T staging, No (%) | Â | Â | 0.192 | Â | Â | 0.184 | Â | Â | 0.126 |
 T1 | 3 (4.28) | 4 (6.89) |  | 2 (88.24) | 1 (3.44) |  | 0 (0.00) | 1 (7.14) |  |
 T2 | 54 (77.14) | 49 (84.48) |  | 26 (11.76) | 25 (86.20) |  | 13 (81.25) | 11 (78.57) |  |
 T3 | 5 (71.42) | 2 (3.44) |  | 3 (8.57) | 2 (6.89) |  | 1 (6.25) | 0 (0.00) |  |
 T4 | 8 (11.42) | 3 (5.17) |  | 4 (1.42) | 1 (3.44) |  | 2 (12.50) | 2 (14.28) |  |
N staging, No (%) | Â | Â | 0.012* | Â | Â | 0.039* | Â | Â | 0.046* |
 N0 | 21(30.00) | 7 (12.06) |  | 14 (40.00) | 4 (13.79) |  | 7 (43.75) | 2 (14.28) |  |
 N1 | 42 (60.00) | 33 (56.89) |  | 17 (48.57) | 18 (62.06) |  | 7 (43.75) | 6 (42.85) |  |
 N2 | 7 (10.00) | 16 (27.58) |  | 3 (8.57) | 7 (24.13) |  | 2 (12.50) | 6 (42.85) |  |
 N3 | 0 (0.00) | 2 (3.44) |  | 1 (2.85) | 0 (0.00) |  | 0 (0.00) | 0 (0.00) |  |
ER, No (%) | Â | Â | 0.102 | Â | Â | 0.079 | Â | Â | 0.154 |
 Positive | 48 (68.57) | 30 (51.72) |  | 21 (60.00) | 17 (58.62) |  | 12 (75.00) | 9 (64.28) |  |
 Negative | 22 (31.42) | 28 (48.27) |  | 14 (40.00) | 12 (41.37) |  | 4 (25.00) | 5 (35,71) |  |
PR, No (%) | Â | Â | 0.066 | Â | Â | 0.143 | Â | Â | 0.169 |
 Positive | 41 (58.57) | 23 (39.65) |  | 23 (65.71) | 13 (44.82) |  | 11 (68.75) | 9 (64.28) |  |
 Negative | 29 (41.42) | 35 (60.34) |  | 12 (34.28) | 16 (55.17) |  | 5 (31.25) | 5 (35.71) |  |
HER2, No (%) | Â | Â | 0.013* | Â | Â | 0.050* | Â | Â | 0.048* |
 Positive | 17 (24.28) | 29 (50.00) |  | 13 (52.00) | 19 (65.51) |  | 6 (37.50) | 11 (78.57) |  |
 Negative | 53 (75.71) | 29 (50.00) |  | 22 (62.85) | 10 (34.48) |  | 10 (62.50) | 3 (21.42) |  |
Ki-67, No (%) | Â | Â | 0.078 | Â | Â | 0.043* | Â | Â | 0.169 |
 Positive | 42 (70.00) | 50 (86.20) |  | 29 (82.85) | 22 (75.86) |  | 11 (68.75) | 9 (64.28) |  |
 Negative | 18 (30.00) | 8 (13.80) |  | 6 (17.15) | 7 (24.14) |  | 5 (31.25) | 5 (35.72) |  |
MP, No (%) |  |  | < 0.001* |  |  | < 0.001* |  |  | < 0.001* |
 G1 | 0 (0.00) | 0 (0.00) |  | 0 (0.00) | 0 (0.00) |  | 0 (0.00) | 0 (0.00) |  |
 G2 | 16 (22.86) | 0 (0.00) |  | 5 (14.29) | 0 (0.00) |  | 5 (31.25) | 0 (0.00) |  |
 G3 | 54 (77.14) | 0 (0.00) |  | 30 (85.71) | 0 (0.00) |  | 11 (68.75) | 0 (0.00) |  |
 G4 | 0 (0.00) | 18 (31.03) |  | 0 (0.00) | 14 (48.27) |  | 0 (0.00) | 4 (28.57) |  |
 G5 | 0 (0.00) | 40 (68.96) |  | 0 (0.00) | 15 (51.72) |  | 0 (0.00) | 10 (71.42) |  |