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Table 2 Clinical manifestations of patients with myocarditis

From: Immune checkpoint inhibitor-related myocarditis in patients with lung cancer

Clinical manifestation

Patients (n), No. (%)

Accompanied by symptoms

 

 No

36(54.5)

 Yes

30(45.5)

Electrocardiogram change

 

 No

25(37.)

 Yes

41(62.1)

Elevated biomarkers

 

 Only CK-MB

10(15.2)

 Only hs-cTnI

10(15.2)

 Both

45(68.1)

Other elevated biomarkers

 

 TC

45 (68.2)

 TG

44 (66.7)

 NLR

21 (31.8)

Types of myocarditis

 

 Definite myocarditis

1(1.5)

 Probable myocarditis

5(7.6)

 Possible myocarditis

60(90.9)

Grade of myocarditis

 

 G1

57(86.4)

 G2

5(7.6)

 G3

2(3.0)

 G4

2(3.0)

Echocardiography changes

 

 No

57(86.4)

 Left ventricular diastolic hypoplasia

7(10.)

 Ventricular wall segmental motion abnormalities

2(3.0)

cMRI change

 

 No

65(98.5)

 Oedema and delayed enhancement

1 (1.5)

Concurrent other irAEs

 

 No

36(54.5)

 Thyroiditis

8(12.1)

 Pneumonia

7(10.6)

 Liver dysfunction

7(10.6)

 Rash

6(9.1)

 Myositis

3(4.5)

 Renal injury

3(4.5)

 Heart failure

2(3.0)

 Pancreatitis

2(3.0)

 Venous thromboembolism

2(3.0)

 Neuritis

1(1.5)

 Adrenal insufficiency

1(1.5)

  1. CK-MB, serum creatine kinase isoenzyme, MB; hs-cTnI, high-sensitivity troponin I; TC, total cholesterol; TG, triglycerides; NLR, Neutrophil-to-lymphocyte ratio; G1-4, grade 1–4; cMRI, cardiovascular magnetic resonance imaging; irAEs, immune-related adverse events