Table 1 ESR1 and PIK3CA peptides analyzed in this study
From: HLA class II-restricted T cell epitopes in public neoantigens of ESR1 and PIK3CA in breast cancer
Peptide | Gene | Amino acid substitution | Peptide sequencea | %Rankb | |
|---|---|---|---|---|---|
DRB4 *01:03 | A *24:02 | ||||
ES#1_K303R | ESR1 | K303R | WPSPLMIKRSKRNSL | 25.9 | 19.8 |
ES#2_E380Q | ESR1 | E380Q | DLTLHDQVHLLQCAW | 14.9 | 6.5 |
ES#3_S463P | ESR1 | S463P | GVYTFLPSTLKSLEE | 65.7 | 0.0 |
ES#4_L536H | ESR1 | L536H | VVPHYDLLLEMLDAH | 31.4 | 0.4 |
ES#5_Y537S | ESR1 | Y537S | CKNVVPLSDLLLEML | 46.2 | 2.2 |
ES#6_Y537N | ESR1 | Y537N | CKNVVPLNDLLLEML | 43.6 | 2.4 |
ES#7_D538G | ESR1 | D538G | CKNVVPLYGLLLEML | 62.9 | 0.4 |
PIK#1_N345K | PIK3CA | N345K | TYVKVNIRDIDKIYV | 3.4 | 10.3 |
PIK#2_C420R | PIK3CA | C420R | EEHRPLAWGNINLFD | 53.4 | 8.5 |
PIK#3_E542K | PIK3CA | E542K | PLSKITEQEKDFLWS | 5.0 | 10.5 |
PIK#4_E545K | PIK3CA | E545K | PLSEITKQEKDFLWS | 3.9 | 3.4 |
PIK#5_E545A | PIK3CA | E545A | PLSEITAQEKDFLWS | 2.7 | 1.7 |
PIK#6_E726K | PIK3CA | E726K | LTDILKQEKKDKTQK | 1.8 | 45.5 |
PIK#7_H1047R | PIK3CA | H1047R | LEYFMKQMNDARHGG | 3.4 | 34.0 |
PIK#8_H1047L | PIK3CA | H1047L | LEYFMKQMNDALHGG | 3.0 | 7.1 |
PIK#9_H1047Y | PIK3CA | H1047Y | LEYFMKQMNDAYHGG | 3.5 | 8.8 |
PIK#10_G1049R | PIK3CA | G1049R | YFMKQMNDAHHRGWT | 14.3 | 5.6 |