Table 1 Influence of the co-cultivation and hypoxia on the leukemic and the feeder cells
From: Interactions between leukemia and feeders in co-cultivation under hypoxia
SD-1 | individual cultivation | co-cultivation | ||
|---|---|---|---|---|
NHDF | hMSCs | |||
proliferation | NX = HX | ↑↑ NX > ↑↑ HX | ↑ NX > HX | |
mt. activity | NX = HX | ↓ NX = ↓ HX | ↓ NX = ↓ HX | |
2-DG uptake | NX = HX | ↓ NX < ↑↑ HX | ↓ NX < ↑ HX | |
cell bonds | strong NX = strong HX | strong NX > weak HX | ||
Genes | GLUT1 | NX = HX | ↓ NX = ↓ HX | ↓ NX = ↓ HX |
SDHA | NX = HX | NX = HX | ↓ NX < HX | |
HIF1α | NX < < HX | ↑ NX < ↑↑ HX | ↑ NX < ↑ HX | |
PGE | NX > HX | ↑ NX < ↑ HX | NX = HX | |
UPF26K | ||||
proliferation | NX = HX | ↓↓ NX < ↓↓ HX | ↓↓ NX < ↓↓ HX | |
mt. activity | NX = HX | ↑ NX > ↑ HX | NX > ↓ HX | |
2-DG uptake | NX = HX | ↑ NX = ↑ HX | NX = HX | |
cell bonds | weak NX = weak HX | strong NX > weak HX | ||
Genes | GLUT1 | NX = HX | NX < ↑ HX | ↑ NX = ↑ HX |
SDHA | NX = HX | NX = HX | NX = HX | |
HIF1α | NX = HX | ↑ NX < ↑ HX | NX < ↑ HX | |
PGE | NX = HX | NX = HX | NX = HX | |
NHDF | individual cultivation | co-cultivation | ||
SD-1 | UPF26K | |||
proliferation | NX < HX | ↓↓ NX = ↓↓ HX | ↑↑ NX < ↑↑ HX | |
mt. activity | NX > HX | ↑ NX > ↑ HX | NX > ↓ HX | |
2-DG uptake | NX = HX | ↓ NX = ↓ HX | ↑ NX = ↑ HX | |
mitochondria | elong. NX / frag. HX | ↑ dense, elong. NX / ↑ frag. HX | elong. NX / ↓ frag. HX | |
Genes | GLUT1 | NX = HX | ↓ NX < HX | ↓ NX = ↓ HX |
SDHA | NX = HX | ↑↑ NX < ↑↑ HX | ↓ NX = ↓ HX | |
HIF1α | NX > HX | ↓↓ NX = ↓↓ HX | ↓ NX = ↓ HX | |
PGE | NX = HX | ↑ NX = ↑ HX | ↓ NX = ↓ HX | |
hMSCs | ||||
proliferation | NX = HX | NX = ↑↑ HX | NX < ↑↑ HX | |
mt. activity | NX = HX | ↓ NX = ↓ HX | NX > ↓ HX | |
2-DG uptake | NX = HX | ↓ NX = ↓ HX | ↑ NX = ↑ HX | |
mitochondria | elong. NX / frag.HX | ↑ frag. NX / ↑ frag. HX | frag. NX / ↑ frag. HX | |
Genes | GLUT1 | NX < HX | ↓ NX = ↓ HX | ↑ NX = ↓ HX |
SDHA | NX < HX | ↑ NX = ↑ HX | ↓ NX = ↓ HX | |
HIF1α | NX < HX | NX = ↓ HX | NX < ↓ HX | |
PGE | NX = HX | NX = HX | ↓ NX = HX | |