Fig. 3

Baseline and 10-year follow-up MRI images of the brains of two male patients in their late 40 s with missense mutations and brain hemangioblastomas with different volumes at baseline. A Axial T2-weighted and enhanced T1-weighted images reveal a relatively large hemangioblastoma (2.5 cm) in the right cerebellum of one patient. B The 10-year-follow-up MRI images show a marked increase in size (4.0 cm), with significant increase in the cystic portion. C Axial enhanced T1-weighted image reveals a tiny hemangioblastoma (0.2 cm) in the right cerebellum of another patient. D The 10-year-follow-up axial enhanced T1-weighted image shows a marginal increase in the size (0.5 cm) of the tumor