Fig. 3

The correlation of risk signature and immune microenvironment of HNSCC. (A) Patients in the high-risk group have high CCP scores. (B) Difference between low- and high-risk groups at six energy metabolism pathways. (C) In HNSCC, 53 immunoregulators are differentially expressed (MHC, receptors, and chemokines). (D) Difference between low- and high-risk groups at distinct stages of the cancer-immune cycle. (E) Relationship of the risk score with infiltration levels of severe TIICs, as determined by seven separate algorithms