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Table 4 Additive interaction between TyG index and its combination with obesity indicators and genetic risk on the risk of breast cancer among postmenopausal women in UK Biobank

From: Association between triglyceride-glucose related indicators, genetic risk, and incident breast cancer among postmenopausal women in UK Biobank

 

PRS category

Intermediate genetic risk

High genetic risk

RERI (95% CI)

AP (95% CI)

RERI (95% CI)

AP (95% CI)

TyG

 Quartile 2

0.22 (−0.27, 0.71)

0.10 (−0.13, 0.34)

0.01 (−0.61, 0.63)

0.00 (−0.16, 0.17)

 Quartile 3

0.16 (−0.34, 0.67)

0.08 (−0.17, 0.33)

0.08 (−0.56, 0.73)

0.02 (−0.14, 0.18)

 Quartile 4

−0.03 (−0.59, 0.52)

−0.02 (−0.26, 0.23)

−0.19 (−0.93, 0.55)

−0.05 (−0.22, 0.13)

TyG-WC

 Quartile 2

0.06 (−0.51, 0.62)

0.02 (−0.22, 0.27)

0.85 (0.22, 1.48)

0.19 (0.05, 0.33)

 Quartile 3

−0.08 (−0.66, 0.51)

−0.03 (−0.30, 0.23)

1.12 (0.49, 1.75)

0.24 (0.10, 0.37)

 Quartile 4

0.54 (−0.02, 1.10)

0.18 (−0.01, 0.38)

1.00 (0.33, 1.66)

0.21 (0.07, 0.34)

TyG-WHtR

 Quartile 2

0.33 (−0.12, 0.79)

0.17 (−0.07, 0.40)

0.55 (0.01, 1.10)

0.15 (0.00, 0.30)

 Quartile 3

0.05 (−0.44, 0.54)

0.03 (−0.24, 0.29)

0.83 (0.28, 1.38)

0.21 (0.07, 0.34)

 Quartile 4

0.69 (0.22, 1.15)

0.28 (0.09, 0.48)

1.04 (0.46, 1.61)

0.25 (0.11, 0.38)

TyG-WHR

 Quartile 2

0.00 (−0.50, 0.50)

0.00 (−0.27, 0.27)

0.80 (0.24, 1.36)

0.20 (0.06, 0.34)

 Quartile 3

−0.13 (−0.67, 0.40)

−0.07 (−0.33, 0.20)

0.41 (−0.16, 0.99)

0.11 (−0.05, 0.26)

 Quartile 4

0.17 (−0.34, 0.68)

0.08 (−0.15, 0.31)

0.78 (0.18, 1.37)

0.19 (0.04, 0.33)

TyG-BMI

 Quartile 2

0.22 (−0.33, 0.77)

0.09 (−0.15, 0.33)

0.31 (−0.35, 0.97)

0.07 (−0.08, 0.22)

 Quartile 3

0.04 (−0.53, 0.60)

0.02 (−0.24, 0.27)

0.48 (−0.17, 1.13)

0.11 (−0.04, 0.25)

 Quartile 4

0.65 (0.11, 1.20)

0.23 (0.03, 0.42)

0.96 (0.28, 1.64)

0.19 (0.06, 0.32)

  1. Model was adjusted for age, Townsend Deprivation Index, first five principal components of ancestry, genotyping batch, walking, education, smoking, drinking, family history of breast cancer, history of cardiovascular diseases, screening, contraceptives, age at menarche, number of live births, hormone replacement therapy, age at menopause, diabetes, fasting time, cholesterol, high-density cholesterol
  2. To estimate RERI and AP, the lowest TyG index and its combination with obesity indicators category and the lowest genetic risk groups were the reference categories
  3. TyG triglyceride-glucose, HR hazard ratio, CI confidence interval, PRS polygenic risk score, RERI relative excess risk due to interaction, AP the attributable proportion due to the interaction, TyG-WC triglyceride glucose-waist circumference, TyG-WHtR triglyceride glucose-waist to height ratio, TyG-WHR triglyceride glucose-waist to hip ratio, TyG-BMI triglyceride glucose-body mass index
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BMC Cancer

ISSN: 1471-2407

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