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Table 3 Association between genetic risk and breast cancer risk among postmenopausal women in UK Biobank (n = 71,863)

From: Association between triglyceride-glucose related indicators, genetic risk, and incident breast cancer among postmenopausal women in UK Biobank

 

No. of cases/person-years

Model 1, HR (95% CI)

Model 2, HR (95% CI)

Model 3, HR (95% CI)

PRS category

 Low genetic risk

244/194,193

1.00

1.00

1.00

 Intermediate genetic risk

970/385,199

2.01 (1.74–2.31)

1.99 (1.73–2.29)

1.99 (1.73–2.29)

 High genetic risk

1862/377,390

3.94 (3.45–4.50)

3.87 (3.38–4.42)

3.86 (3.38–4.42)

 Per 1-SD increase

 

1.75 (1.69–1.81)

1.73 (1.67–1.80)

1.73 (1.67–1.80)

 P for trend

 

 < 0.001

 < 0.001

 < 0.001

  1. TyG, triglyceride-glucose, HR hazard ratio, CI confidence interval, SD standard deviation
  2. Model 1: adjusted for age, Townsend Deprivation Index, first five principal components of ancestry and genotyping batch
  3. Model 2: further adjusted for walking, education, smoking, drinking, family history of breast cancer, history of cardiovascular diseases, screening, contraceptives, age at menarche, number of live births, hormone replacement therapy, age at menopause
  4. Model 3: further adjusted for diabetes, fasting time, cholesterol, high-density cholesterol
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BMC Cancer

ISSN: 1471-2407

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