Table 2 Associations between TyG index and its combination with obesity indicators and breast cancer risk among postmenopausal women in UK Biobank (n = 83,873)

TyG

 Median

8.03

8.42

8.75

9.20

 No. of cases/person-years

838/279,674

891/278,915

878/278,589

954/278,128

Model 1, HR (95% CI)

1.00

1.06 (0.96–1.16)

1.04 (0.95–1.14)

1.13 (1.03–1.24)

1.04 (1.00–1.07)

0.017

Model 2, HR (95% CI)

1.00

1.06 (0.96–1.16)

1.04 (0.95–1.14)

1.13 (1.03–1.24)

1.04 (1.00–1.07)

0.019

Model 3, HR (95% CI)

1.00

1.06 (0.96–1.16)

1.04 (0.94–1.15)

1.12 (1.01–1.25)

1.03 (0.99–1.08)

0.059

TyG-WC

 Median

606.3

681.04

750.74

860.56

 No. of cases/person-years

727/278,955

905/279,921

918/278,975

1011/277,455

Model 1, HR (95% CI)

1.00

1.22 (1.11–1.35)

1.24 (1.12–1.36)

1.37 (1.24–1.50)

1.10 (1.07–1.14)

 < 0.001

Model 2, HR (95% CI)

1.00

1.22 (1.11–1.35)

1.23 (1.12–1.36)

1.36 (1.23–1.49)

1.10 (1.06–1.13)

 < 0.001

Model 3, HR (95% CI)

1.00

1.22 (1.11–1.35)

1.23 (1.12–1.36)

1.35 (1.23–1.49)

1.10 (1.06–1.14)

 < 0.001

TyG-WHtR

 Median

3.73

4.20

4.64

5.33

 No. of cases/person-years

786/279,386

853/279,531

922/279,085

1000/277,307

Model 1, HR (95% CI)

1.00

1.05 (0.95–1.15)

1.09 (0.99–1.20)

1.17 (1.06–1.28)

1.05 (1.02–1.08)

 < 0.001

Model 2, HR (95% CI)

1.00

1.05 (0.95–1.15)

1.09 (0.99–1.20)

1.16 (1.06–1.28)

1.05 (1.01–1.08)

 < 0.001

Model 3, HR (95% CI)

1.00

1.05 (0.95–1.15)

1.09 (0.99–1.20)

1.16 (1.05–1.28)

1.05 (1.01–1.08)

 < 0.001

TyG-WHR

 Median

6.22

6.76

7.23

7.88

 No. of cases/person-years

815/280,358

867/279,793

908/278,957

971/276,199

Model 1, HR (95% CI)

1.00

1.05(0.96–1.14)

1.08(0.99–1.17)

1.21(1.11–1.31)

1.06(1.03–1.10)

0.001

Model 2, HR (95% CI)

1.00

1.04(0.96–1.14)

1.08(0.99–1.18)

1.22(1.12–1.32)

1.07(1.04–1.10)

0.001

Model 3, HR (95% CI)

1.00

1.04(0.96–1.14)

1.08(0.99–1.18)

1.22(1.12–1.33)

1.07(1.03–1.10)

0.003

TyG-BMI

 Median

187.23

213.12

238.40

282.69

 No. of cases/person-years

765/278,469

880/279,486

894/278,896

1022/278,456

Model 1, HR (95% CI)

1.00

1.14 (1.03–1.25)

1.15 (1.04–1.26)

1.32 (1.20–1.45)

1.10 (1.06–1.13)

 < 0.001

Model 2, HR (95% CI)

1.00

1.13 (1.03–1.25)

1.14 (1.04–1.26)

1.31 (1.19–1.44)

1.09 (1.06–1.13)

 < 0.001

Model 3, HR (95% CI)

1.00

1.13 (1.03–1.25)

1.14 (1.04–1.26)

1.31 (1.19–1.44)

1.09 (1.06–1.13)

 < 0.001