Table 1 Baseline characteristics according to quartiles of TyG index among postmenopausal women (n = 83,873)
Characteristica | Total | Quartiles of TyG index | P value | |||
|---|---|---|---|---|---|---|
Q1 (6.86–8.24) | Q2 (8.24–8.58) | Q3 (8.58–8.94) | Q4 (8.94–10.94) | |||
Number of participants | 83873 | 20916 | 20969 | 20956 | 21032 | |
Age, years (median [IQR]) | 61.00 [57.00, 64.00] | 60.00 [57.00, 64.00] | 60.00 [57.00, 64.00] | 61.00 [57.00, 64.00] | 61.00 [57.00, 64.00] | < 0.001 |
TDI (median [IQR]) | −2.38 [−3.74, −0.01] | −2.39 [−3.75, −0.03] | −2.38 [−3.75, 0.00] | −2.37 [−3.76, −0.01] | −2.37 [−3.72, −0.02] | 0.902 |
Race, (%) | 0.006 | |||||
White | 80894 (96.4) | 20214 (96.6) | 20236 (96.5) | 20197 (96.4) | 20247 (96.3) | |
Others | 2748 (3.3) | 666 (3.2) | 662 (3.2) | 707 (3.4) | 713 (3.4) | |
Missing | 231 (0.3) | 36 (0.2) | 71 (0.3) | 52 (0.2) | 72 (0.3) | |
Education status, (%) | 0.428 | |||||
College degree or above | 24143 (28.8) | 6098 (29.2) | 6057 (28.9) | 5984 (28.6) | 6004 (28.5) | |
Others | 58863 (70.2) | 14619 (69.9) | 14695 (70.1) | 14734 (70.3) | 14815 (70.4) | |
Missing | 867 (1.0) | 199 (1.0) | 217 (1.0) | 238 (1.1) | 213 (1.0) | |
Walking, minutes/day (median [IQR]) | 30.00 [20.00, 60.00] | 30.00 [20.00, 60.00] | 30.00 [20.00, 60.00] | 30.00 [20.00, 60.00] | 30.00 [20.00, 60.00] | 0.413 |
Smoking, (%) | 0.799 | |||||
Never | 49283 (58.8) | 12287 (58.7) | 12337 (58.8) | 12262 (58.5) | 12397 (58.9) | |
Previous | 27529 (32.8) | 6849 (32.7) | 6838 (32.6) | 6903 (32.9) | 6939 (33.0) | |
Current | 6740 (8.0) | 1702 (8.1) | 1712 (8.2) | 1707 (8.1) | 1619 (7.7) | |
Missing | 321 (0.4) | 78 (0.4) | 82 (0.4) | 84 (0.4) | 77 (0.4) | |
Drinking, (%) | 0.328 | |||||
Never | 4578 (5.5) | 1133 (5.4) | 1194 (5.7) | 1133 (5.4) | 1118 (5.3) | |
Previous | 2758 (3.3) | 646 (3.1) | 709 (3.4) | 693 (3.3) | 710 (3.4) | |
Current | 76457 (91.2) | 19113 (91.4) | 19050 (90.8) | 19106 (91.2) | 19188 (91.2) | |
Missing | 80 (0.1) | 24 (0.1) | 16 (0.1) | 24 (0.1) | 16 (0.1) | |
History of cardiovascular diseases, (%) | < 0.001 | |||||
No | 63611 (75.8) | 16057 (76.8) | 15975 (76.2) | 15830 (75.5) | 15749 (74.9) | |
Yes | 20118 (24.0) | 4819 (23.0) | 4961 (23.7) | 5088 (24.3) | 5250 (25.0) | |
Missing | 144 (0.2) | 40 (0.2) | 33 (0.2) | 38 (0.2) | 33 (0.2) | |
History of diabetes, (%) | < 0.001 | |||||
No | 82756 (98.7) | 20735 (99.1) | 20750 (99.0) | 20679 (98.7) | 20592 (97.9) | |
Yes | 978 (1.2) | 157 (0.8) | 184 (0.9) | 234 (1.1) | 403 (1.9) | |
Missing | 139 (0.2) | 24 (0.1) | 35 (0.2) | 43 (0.2) | 37 (0.2) | |
Family history of breast cancer, (%) | 0.461 | |||||
No | 73119 (87.2) | 18280 (87.4) | 18214 (86.9) | 18293 (87.3) | 18332 (87.2) | |
Yes | 9597 (11.4) | 2331 (11.1) | 2459 (11.7) | 2388 (11.4) | 2419 (11.5) | |
Missing | 1157 (1.4) | 305 (1.5) | 296 (1.4) | 275 (1.3) | 281 (1.3) | |
BMI (mean (SD)) | 27.01 (4.89) | 26.86 (4.84) | 26.97 (4.82) | 26.99 (4.89) | 27.22 (5.02) | < 0.001 |
Waist circumference, cm (mean (SD)) | 84.66 (11.97) | 84.22 (11.84) | 84.57 (11.80) | 84.69 (11.98) | 85.14 (12.23) | < 0.001 |
Hip circumference, cm (mean (SD)) | 103.30 (9.96) | 103.08 (9.85) | 103.27 (9.82) | 103.24 (9.91) | 103.62 (10.23) | < 0.001 |
Standing height, cm (mean (SD)) | 162.09 (6.15) | 162.10 (6.18) | 162.08 (6.14) | 162.14 (6.17) | 162.03 (6.13) | 0.332 |
Breast cancer screening, (%) | 0.001 | |||||
No | 3317 (4.0) | 874 (4.2) | 848 (4.0) | 857 (4.1) | 738 (3.5) | |
Yes | 80512 (96.0) | 20024 (95.7) | 20111 (95.9) | 20093 (95.9) | 20284 (96.4) | |
Missing | 44 (0.1) | 18 (0.1) | 10 (0.0) | 6 (0.0) | 10 (0.0) | |
Age at menarche, years (mean (SD)) | 12.95 (1.58) | 12.96 (1.58) | 12.97 (1.58) | 12.94 (1.57) | 12.94 (1.58) | 0.134 |
Age at menopause, years (mean (SD)) | 49.84 (4.54) | 49.80 (4.51) | 49.86 (4.55) | 49.78 (4.53) | 49.91 (4.57) | 0.011 |
Number of live births, (%) | 0.751 | |||||
0 | 13198 (15.7) | 3306 (15.8) | 3260 (15.5) | 3324 (15.9) | 3308 (15.7) | |
1 | 10241 (12.2) | 2543 (12.2) | 2565 (12.2) | 2571 (12.3) | 2562 (12.2) | |
2 | 38958 (46.4) | 9720 (46.5) | 9804 (46.8) | 9761 (46.6) | 9673 (46.0) | |
> = 3 | 21414 (25.5) | 5329 (25.5) | 5324 (25.4) | 5282 (25.2) | 5479 (26.1) | |
Missing | 62 (0.1) | 18 (0.1) | 16 (0.1) | 18 (0.1) | 10 (0.0) | |
Oral contraceptive use, (%) | 0.001 | |||||
No | 17805 (21.2) | 4247 (20.3) | 4470 (21.3) | 4450 (21.2) | 4638 (22.1) | |
Yes | 65877 (78.5) | 16612 (79.4) | 16459 (78.5) | 16456 (78.5) | 16350 (77.7) | |
Missing | 191 (0.2) | 57 (0.3) | 40 (0.2) | 50 (0.2) | 44 (0.2) | |
Fasting time, hours (median [IQR]) | 3.00 [3.00, 4.00] | 3.00 [3.00, 4.00] | 3.00 [3.00, 4.00] | 3.00 [3.00, 4.00] | 3.00 [3.00, 4.00] | < 0.001 |
HbA1c, mmol/L (median [IQR]) | 35.60 [33.40, 37.80] | 35.40 [33.30, 37.50] | 35.60 [33.40, 37.80] | 35.60 [33.50, 37.90] | 35.80 [33.60, 38.10] | < 0.001 |
Hormone replacement therapy, (%) | 0.352 | |||||
No | 41770 (49.8) | 10331 (49.4) | 10398 (49.6) | 10441 (49.8) | 10600 (50.4) | |
Yes | 41898 (50.0) | 10534 (50.4) | 10515 (50.1) | 10460 (49.9) | 10389 (49.4) | |
Missing | 205 (0.2) | 51 (0.2) | 56 (0.3) | 55 (0.3) | 43 (0.2) | |
TC, mmol/L (mean (SD)) | 5.87 (1.13) | 5.44 (0.98) | 5.76 (1.03) | 5.98 (1.10) | 6.30 (1.21) | < 0.001 |
TG, mmol/L (median [IQR]) | 1.33 [0.97, 1.90] | 0.79 [0.68, 0.90] | 1.15 [1.04, 1.26] | 1.58 [1.43, 1.76] | 2.44 [2.10, 3.01] | < 0.001 |
HDC, mmol/L (mean (SD)) | 1.59 (0.36) | 1.77 (0.38) | 1.66 (0.35) | 1.55 (0.32) | 1.40 (0.29) | < 0.001 |
LDC, mmol/L (mean (SD)) | 3.63 (0.87) | 3.22 (0.72) | 3.53 (0.78) | 3.75 (0.85) | 3.99 (0.93) | < 0.001 |
Glucose, mmol/L (median [IQR]) | 4.94 [4.64, 5.29] | 4.80 [4.50, 5.10] | 4.93 [4.63, 5.25] | 4.98 [4.68, 5.33] | 5.09 [4.77, 5.50] | < 0.001 |
CRP, mg/L (median [IQR]) | 1.48 [0.72, 3.06] | 1.43 [0.69, 2.94] | 1.47 [0.71, 3.01] | 1.49 [0.73, 3.06] | 1.54 [0.74, 3.24] | < 0.001 |
SHBG, nmol/L (median [IQR]) | 56.44 [40.95, 75.87] | 57.31 [41.92, 76.89] | 56.63 [41.23, 76.00] | 56.36 [40.73, 75.96] | 55.44 [39.73, 74.62] | < 0.001 |
Testosterone, nmol/L (median [IQR]) | 0.97 [0.69, 1.32] | 0.97 [0.69, 1.31] | 0.97 [0.69, 1.31] | 0.97 [0.70, 1.33] | 0.97 [0.69, 1.33] | 0.345 |