Reirradiation based on diffusion-weighted magnetic resonance imaging-guided dose- painting for locally advanced recurrent nasopharyngeal carcinoma: a phase 2 randomized controlled trial

Table 1 Baseline clinical characteristics

Characteristics	DWI-Guided DP-IMRT group No. of patients	Conventional MRI-based IMRT No. of patients	P value
Total	75	75
Age, y
Median	53	55
Range	18–70	22–70
Sex			0.198
Male	65	59
Female	10	16
Karnofsky Scale			0.119
90–100	67	72
70–80	8	3
EBV-DNA			0.072
≥ 400 copies/ml	47	36
< 400 copies/ml	28	39
Recurrent stage			0.413
III	45	40
IV	30	35
Recurrent T Stage			0.174
rT1	11	6
rT2	11	13
rT3	34	29
rT4	19	27
Recurrent N Stage			0.886
rN0	33	32
rN1	10	7
rN2	20	27
rN3	12	9	0.056
Median time interval between 1st and 2nd course of RT (years, range)	2.3 (1.6–4.9)	2.4 (1.8–4.5)

ISSN: 1471-2407