Fig. 6

USP35 related prognostic analysis in KIRC. A Univariate and multivariate Cox regression analysis for USP35 expression and other clinical factors in KIRC. B Non-linear relationship between USP35 expression and hazard ratio (HR), showing increased risk with higher USP35 expression levels. C ROC curve analysis of USP35 expression predicting 1-year, 5-year, and 10-year survival in KIRC patients. D Meta-analysis showing the association of USP35 expression with hazard ratios across multiple datasets. E–G Kaplan–Meier survival curves showing the correlation between high and low USP35 expression with disease-specific survival (E), progression-free interval (F), and overall survival (G) in KIRC. H-J Stratified analysis of USP35 expression into quartiles (Q1-Q4), showing significant differences in disease-specific survival (H), progression-free interval (I), and overall survival (J)