Table 2 The top 20 metabolites with significant differences between HCT and DNT

PI (6 keto-PGF1alpha/16:0)

up

ESI-

2.4039

1.3273

0.4085

1.514E-07

N-Amidino-L-aspartate

down

ESI+

2.9828

0.6812

-0.5538

3.926E-07

Lupex

down

ESI-

2.9952

0.6492

-0.6233

6.446E-07

13,16,19-Docosatrienoic acid

up

ESI-

2.3091

1.2007

0.2639

0.000001507

2,3,4,5-Tetrahydro-2-pyridinecarboxylic acid

down

ESI-

3.1523

0.6443

-0.6342

0.000002089

PA (18:2(9Z,12Z)/20:1(11Z))

up

ESI-

1.4519

1.0623

0.0872

0.000003408

(2E)-Non-2-enedioylcarnitine

down

ESI-

2.7138

0.6521

-0.6168

0.000006465

Azaserine

down

ESI+

2.5226

0.7374

-0.4395

0.000007775

Tetracosapentenoic acid

up

ESI-

2.2002

1.1919

0.2533

0.000009136

Stearoyllactic acid

up

ESI-

1.5042

1.0968

0.1333

0.00000983

5,8,11-Eicosatrienoic acid

up

ESI-

1.9709

1.199

0.2618

0.00001021

Abacavir

down

ESI-

2.8114

0.6381

-0.6481

0.00001227

Cytidine-5’-diphosphocholine

up

ESI-

2.6111

1.3479

0.4307

0.00001821

(6R)-Folinic acid

down

ESI-

2.9997

0.6269

-0.6737

0.00002248

Citric Acid

up

ESI-

1.1145

1.0479

0.0675

0.00002444

PG (18:2(9Z,12Z)/18:1(9Z))

up

ESI-

1.7352

1.0973

0.134

0.00002644

PG (20:3(6,8,11)-OH(5)/18:2(9Z,12Z))

up

ESI-

1.8584

1.136

0.184

0.00003883

6-Lactoyltetrahydropterin

down

ESI-

2.2779

0.7165

-0.481

0.00004214

Pirbuterol

down

ESI-

2.877

0.5816

-0.7819

0.00004833

L-Hexanoylcarnitine

down

ESI+

2.2113

0.8171

-0.2914

0.00005157