Table 1 The PPI analysis identified the top 25 proteins with the highest degree of connectivity

POLR1B

DNA-directed RNA polymerase I subunit RPA2

up

< 0.001

120

1.31

MRTO4

mRNA turnover protein 4 homolog

up

< 0.001

128

1.17

GTPBP4

GTP-binding protein 4

up

< 0.001

111

1.53

NIFK

MKI67 FHA domain-interacting nucleolar phosphoprotein

up

< 0.001

107

1.35

TYMS

Thymidylate synthase

up

< 0.001

104

5.21

POLR1A

DNA-directed RNA polymerase I subunit RPA1

up

< 0.001

117

1.04

MRPL4

39 S ribosomal protein L4

up

< 0.001

111

1.10

CDK1

Cyclin-dependent kinase 1

up

< 0.001

117

2.06

BRIX1

Ribosome biogenesis protein BRX1 homolog

up

< 0.001

104

1.31

GRWD1

Glutamate-rich WD repeat-containing protein 1

up

< 0.001

101

1.21

MRPL3

39 S ribosomal protein L3

up

< 0.001

112

1.01

RPF2

Ribosome production factor 2 homolog

up

< 0.001

105

1.67

DDX56

Probable ATP-dependent RNA helicase DDX56

up

0.01

113

1.18

KRR1

KRR1 small subunit processome component homolog

up

< 0.001

100

1.23

RPL7L1

60 S ribosomal protein L7-like 1

up

< 0.001

100

1.07

MRPS7

28 S ribosomal protein S7

up

0.02

110

1.12

FTSJ3

pre-rRNA 2’-O-ribose RNA methyltransferase FTSJ3

up

< 0.001

101

1.55

GNL3

Guanine nucleotide-binding protein-like 3

up

0.01

104

1.37

DDX21

Nucleolar RNA helicase 2

up

0.02

109

1.71

PES1

Pescadillo homolog

up

< 0.001

101

1.32

NOP2

Probable 28 S rRNA (cytosine (4447)-C (5))-methyltransferase

up

0.01

104

1.46

BOP1

Ribosome biogenesis protein BOP1

up

0.01

103

1.40

WDR12

Ribosome biogenesis protein WDR12

up

< 0.001

99

1.21

AURKB

Aurora kinase B

up

0.02

98

9.86

GNL3L

Guanine nucleotide-binding protein-like 3-like protein

up

0.02

98

1.88