Fig. 6
From: Comprehensive molecular characteristics of hepatocellular carcinoma based on multi-omics analysis
Functional analysis of differentially expressed metabolites. (A) KEGG annotation analysis was performed to identify differentially expressed metabolites. (B) KEGG enrichment analysis was carried out to determine the significance of these differentially expressed metabolites in metabolic pathways. Abbreviations: M, metabolism; HD, human diseases; EIP, environmental information processing; OS, organismal systems. (C) Differential abundance score map of KEGG pathways. The horizontal axis represents the DA Score and the vertical axis indicates the name of each metabolic pathway in KEGG database. The DA Score reflects overall changes in all annotated metabolites within a given pathway, with a score of 1 indicating up-regulation and − 1 indicating down-regulation for all annotated differential metabolites within that pathway. The length of line segments corresponds to absolute values of DA Scores, while dot sizes indicate numbers of differential metabolites annotated in each pathway