Fig. 5
From: Comprehensive molecular characteristics of hepatocellular carcinoma based on multi-omics analysis

The metabolite features with the top 20 differences between HCT and DNT. (A) A correlation heatmap was generated for the top 20 differentially expressed metabolites. (B) VIP value analysis was performed on the top 20 differential metabolites. On the left side, a dendrogram of metabolite clustering is presented, where closer branches indicate similar expression patterns among all metabolites in the samples. Each column represents a sample. Each row represents a metabolite, and color indicates its relative expression level in this group of samples. The gradient color block provides a visual representation of the correspondence between color gradient and numerical size. On the right side, a VIP bar chart displays the contribution value of each metabolite to the difference between two groups (threshold set at 1). A longer bar indicates a greater difference in abundance between HCT and DNT groups. The color of each bar reflects significance levels (adjusted p-value) for differences between groups: darker colors represent smaller adjusted p-values (-log10(adjusted p-value)). Additionally, asterisks (*) denote P < 0.05, ** denotes P < 0.01, and *** denotes P < 0.001