Fig. 2

Functional analysis of differentially expressed proteins. (A) Subcellular localization mapping of differentially expressed proteins. Abbreviations: PM, plasma membrane; ER, endoplasmic reticulum; EX, extracellular; GA, golgi apparatus; PE, Periplasm; LY, lysosomal. (B) PPI network analysis of differentially expressed proteins. The intensity of the color of the circle in the figure corresponds to the number of nodes connected by the protein; a darker shade indicates a higher number of nodes connected by the protein. (C) GO term analysis for the differentially expressed proteins in HCC. (D) KEGG annotation for the differentially expressed proteins in HCC. (E) GO enrichment analysis for the identification of enriched terms among the differentially expressed proteins. The abscissa represents the enrichment rate, which signifies the ratio of enriched proteins in a specific GO term to the total number of proteins annotated to that term. A higher ratio indicates a greater level of enrichment. The ordinate denotes the GO term itself. Each bubble in the figure corresponds to a distinct GO Term, and its size is proportional to the number of concentrated proteins enriched by that particular term. The varying colors of the bubbles represent adjusted p-values, with smaller values indicating redder hues. Abbreviations: CC, cellular component; BP, biological process; MF, molecular function. (F) KEGG pathway enrichment analysis to identify significantly enriched pathways among the differentially expressed proteins. Abbreviations: M, metabolism; GIP, genetic information processing; HD, human diseases