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Fig. 5 | BMC Cancer

Fig. 5

From: The olfactory receptor OR51E2 regulates prostate cancer aggressiveness and modulates STAT3 in prostate cancer cells and in xenograft tumors

Fig. 5

mRNA transcriptomics analysis of the xenograft tumors. (a) Volcano plot of the dataset with the top-regulated genes based on both FC and P values labeled. (b) MA plot of the dataset with the same genes as in A labeled. (c) Top downregulated Hallmark gene sets determined by a Gene Set Enrichment Analysis. No gene sets were statistically upregulated in this analysis. (d) Heatmap of the top 150 regulated genes by P value. (e) Results of the enrichment analysis on the GO: BP gene sets. (f) Venn diagrams comparing the mRNA transcriptomics analysis to the proteomics analysis. The first Venn diagram shows the total list of input genes/proteins after filtering out low measurements, whereas the second diagram shows the distribution of significant regulations within the overlapping genes/proteins. For all figures, the direction of the comparison is OR51E2 knockout vs. wildtype, i.e. the direction indicated is the change in the cells harboring the OR51E2 knockout

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BMC Cancer

ISSN: 1471-2407

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