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Fig. 4 | BMC Cancer

Fig. 4

From: The combination of poly(ADP-ribose) polymerase inhibitor and statin inhibits the proliferation of human castration-resistant and taxane-resistant prostate cancer cells in vitro and in vivo

Fig. 4

Effect of combination therapy with simvastatin and olaparib on tumor growth and BRCA1 expression in vivo in a 22Rv1 xenograft model. Graphic view of mean tumor volumes in 22Rv1 xenografts. Mice were injected with 22Rv1 cells (3 × 106 per site) and subsequently orally treated with simvastatin (100 mg/kg once daily) with or without olaparib (50 mg/kg once daily). Line graphs, mean (n = 5); bars, standard deviation (SD); *p < 0.05 vs. the other group. BRCA1 mRNA expression in xenograft tissue was analyzed via quantitative real-time PCR (B). Values are expressed as mean ± SD (n = 5). Sim; simvastatin, Ola; olaparib

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BMC Cancer

ISSN: 1471-2407

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