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Fig. 3 | BMC Cancer

Fig. 3

From: The combination of poly(ADP-ribose) polymerase inhibitor and statin inhibits the proliferation of human castration-resistant and taxane-resistant prostate cancer cells in vitro and in vivo

Fig. 3

Effect of combination therapy with simvastatin and olaparib on androgen-independent prostate cancer cells. The cells were then incubated in a medium. After 48 h, the cells were cultured in a medium with or without simvastatin (PC-3, 2 µM; other cells, 5 µM) and olaparib (10 µM). After 72 h for PC-3, LNCaP, and PrSC and 120 h for LNCaP-LA and 22Rv1 cells, the number of viable cells was evaluated using MTS assay (A) and cell counts (B). Values are expressed as mean ± standard deviation (SD) (A; n = 5, B; n = 4). *p < 0.05. Sim; simvastatin, Ola; olaparib

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BMC Cancer

ISSN: 1471-2407

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