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Table 2 Summary of significant changes in the expression of specific core HPARBPs and their downstream binding targets in HCC-related samples. The list named “HCC vs. normal” includes findings from expression in tissues and/or cell lines associated with HCC, as reported in other studies [46,47,48,49,50,51,52,53]. The list named “recurrance after adjuvant HCC vs. normal” includes the results obtained by qRT‒PCR in HCC and normal tissues in this study. Ns, not significant; *P-value < 0.05

From: The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma

Type

Gene

HCC vs. normal

Recurrence after adjuvant therapy HCC vs. normal

Specific Core HPARBPs

ILF3

upregulated

ns

PTBP1

upregulated

ns

U2AF2

upregulated

ns

NCBP2

upregulated

ns

Downstream Binding Targets

LGR4

upregulated

ns

RNF43

upregulated

ns

ZNRF3

downregulated

downregulated [*]