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Fig. 4 | BMC Cancer

Fig. 4

From: Deubiquitinase USP18 mediates cell migration, apoptosis and ferroptosis in lung adenocarcinoma by depending on POU4F1/PRKAA2 axis

Fig. 4

Anti-tumor effects of USP18 silence were rescued by overexpression of POU4F1 in LUAD cells. Four groups: sh-NC, sh-USP18, sh-USP18 + pcDNA, sh-USP18 + POU4F1 were set in H1299 and A549 cells. (A-D) Examination of proliferation (A), migration (B) and apoptosis (C-D) through colony formation assay, wound healing assay and flow cytometric assay. (E-G) ROS (E), MDA (F), and GSH (G) levels were measured via kits. (H) Fe2+ level detection using iron level assay. nP < 0.01, mP < 0.001

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BMC Cancer

ISSN: 1471-2407

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