Fig. 2

Identification of DEGs in colon cancer: (A, B) Heatmap of DEGs in colon cancer and normal samples in the TCGA dataset; volcano plot. The vertical axis represents the -log (adjusted P value [adj. P]), and the horizontal axis represents log2 (FC). Red dots represent upregulated genes, and green dots represent downregulated genes (P < 0.01 and|log2(FC)| > 1). (C) Venn diagram showing the 4 DEGs. (D) K‒M survival analysis of DEGs. (E) It illustrates the receiver operating characteristic (ROC) curves for CDH3, AFP, and CA19-9. The ROC curve was used to evaluate the diagnostic performance of biomarkers. The larger the area under the curve (AUC), the better the diagnostic performance of biomarkers. The figure shows that the AUC of CDH3 is 0.5323, the AUC of AFP is 0.5269, and the AUC of CA19-9 is 0.5257, indicating that CDH3 has some potential as a tumor biomarker