Fig. 6
From: Establishment of a novel mouse model of colorectal cancer by orthotopic transplantation
Investigation of intestinal stem cell and fetal intestinal marker expression in tumors derived from Caco-2 cells. A In Caco-2 cell tumors, an intestinal stem cell marker, ATAD2, was expressed in the majority of tumor cells. The expression levels of ATAD2 were similar in both the central (C) and peripheral (P) regions of large invasive tumors. By contrast, normal mucosa exhibited a significantly lower expression of ATAD2, which was restricted to epithelial cells located at the crypt base. B The mRNA expression levels of fetal intestinal signature genes across eighty CRC cell lines. C A fetal intestinal marker, TACSTD2, was expressed in the majority of tumor cells in Caco-2 tumors. TACSTD2 expression was comparable in both the central (C) and peripheral (P) regions of large invasive tumors. The normal cecal epithelium lacked TACSTD2 expression