Table 6 Hazard ratios for overall survival at 1 year from Cox Regression analysis in patients without metastatic disease (M0). All variables which were significant on univariable analysis were included in the multivariable Cox Regression
Univariate Analysis Hazard Ratio (95% CI) | p-value | Multivariate Analysis Hazard Ratio (95% CI) | p-value | |
|---|---|---|---|---|
Age (< 65/65–74/>74) | 0.82 (0.63–1.08) | 0.156 | ||
Sex (male/female) | 1.14 (0.75–1.74) | 0.535 | ||
ECOG-PS (0–1/2/3–4) | 1.17 (0.84–1.62) | 0.354 | ||
Chemotherapy | 1.06 (0.69–1.63) | 0.795 | ||
Weight Loss (yes/no) | 1.03 (0.67–1.57) | 0.894 | ||
MUST (≥ 1) | 1.00 (0.66–1.52) | 0.990 | ||
BMI < 20 (yes/no) | 1.10 (0.57–2.12) | 0.776 | ||
Low SMI | 1.47 (0.89–2.44) | 0.134 | ||
Low SMD | 1.63 (0.94–2.81) | 0.080 | ||
NLR (< 3/3–5/>5) | 1.79 (1.37–2.35) | < 0.001 | ||
mGPS (0/1/2) | 2.08 (1.58–2.74) | < 0.001 | ||
LDH (≥ 250 Units/L) | 1.73 (1.14–2.62) | 0.011 | ||
LCAS (0/1/2/3) | 1.85 (1.48–2.31) | < 0.001 | 1.85 (1.48–2.31) | < 0.001 |
GRIm (0/1/2) | 1.74 (1.36–2.34) | < 0.001 | 0.78 (0.46–1.33) | 0.361 |
LIPI (0/1/2) | 1.93 (1.44–2.57) | < 0.001 | 1.28 (0.89–1.84) | 0.177 |