Fig. 2
From: Prion protein regulates invasiveness in glioblastoma stem cells
Bulk RNA-Seq data analysis shows that PrPC may modulate migration, proliferation, and stemness-related genes. (a) Volcano plots of the comparison between U87 and U251 WT versus PrPC -KO cells. The plots depict non-significant (gray), downregulated (blue), and upregulated (red) differentially expressed genes (DEGs). (b) Dot plot of key DEGs found in U87 and U251 cells, with size and color relating to p-value and fold change, respectively. (c) Overrepresentation analysis of U87 cells and U251 DEGs. (d) Gene expression of selected DEGs related to stemness maintenance, cellular migration, and invasion in U87 and U251 KO monolayer cells, in relation to their monolayer WT counterparts (p values are described in the Results section)