Fig. 5
From: Genomic investigation of innate sensing pathways in the tumor microenvironment
Intratumor Microbes were Associated with Innate Immune Activation in Mucosal Associated Cancers. A Taxonomic information from tumors within 7 different cancer types was used to make a Bray–Curtis dissimilarity matrix and plotted via a principal component analysis (PCoA). B Stacked barplots of the relative abundance of each phylum of bacteria compared across 7 different cancer types. C Chord plot of the associations between intratumor microbe abundance and ssGSEA scores in colon adenocarcinoma. Associations are colored by correlation coefficients. D Chord plot of the associations between intratumor microbe abundance and ssGSEA scores in lung squamous cell carcinoma. Associations are colored by correlation coefficients. E Scatter plot of the relative abundance of the common resident gut genus, Escherichia, and cGAS activation in colon adenocarcinomas. Pearson R values and P values displayed on graph. (left) Barplot of read counts assigned to Escherichia from COAD and LUSC tumors (right). F Scatter plot of the relative abundance of genus Alcanivorax and NOD activation in lung squamous cell carcinoma. Pearson R values and P values displayed on graph. (left) Barplot of read counts assigned to Alcanivorax from COAD and LUSC tumors (right). Abbreviations: PC (Principal Component), TLR (Toll Like Receptor), CLR (C-type Lectin Receptor), RIG-I (Retinoic acid Inducible Gene I), NOD (Nucleotide Binding Oligomerization Domain), cGAS (Cyclic GMP-AMP Synthase)