Fig. 2

Pan-Cancer Analysis of ssGSEA scores to Quantify Innate Immune System Activation. A Ridgeline plots of ssGSEA scores for five innate immune pathways compared across different cancer types. B A partial cox regression of ssGSEA scores and patient survival was calculated for each cancer type, which controlled for age, gender, pathological stage where applicable, tumor purity, and quantity of immune cell infiltrates. Beta values are shown only for regressions which met a statistical cut off p value < 0.05. C cGAS ssGSEA scores were associated with RNA sequencing data from all 29 cancer types and the statistics were averaged and plotted. GSEA was performed on a list of ranked r statistics from the pan-cancer associations and the top 10 downregulated and upregulated pathways are shown. D TLR ssGSEA scores were associated with RNA sequencing data from all 29 cancer types and the statistics were averaged and plotted. GSEA was performed on a list of ranked r statistics from the pan-cancer associations and the top 10 downregulated and upregulated pathways are shown. Abbreviations: TLR (Toll Like Receptor), CLR (C-type Lectin Receptor), RIG-I (Retinoic acid Inducible Gene I), NOD (Nucleotide Binding Oligomerization Domain), cGAS (Cyclic GMP-AMP Synthase)