Table 3 Measurement timepoints of study objectives

Objective 1 (Primary)

To evaluate the specificity of FIT for the detection of CRC and AA’s in patients with LS.

x

x

x

x

Objective 2 (Secondary a)

To identify and explore acceptability, views, and preferences of FIT in this patient population

x

Objective 3 (Secondary b)

To evaluate the sensitivity of FIT for the detection of CRC in patients with LS

x

x

x

x

Objective 4 (Secondary c)

To evaluate the sensitivity of FIT for the detection of AA’s in patients with LS

x

x

x

x

Objective 5 (Exploratory)

To examine and characterise the faecal microbiome of patients with LS.

x

x

x

x

Objective 6 (Exploratory)

To observe the incidence of interval CRCs for LS patients with FIT negative results (< 6 μg/g f-Hb)

x^a