Table 1 Patient Characteristics and their corresponding hazard ratios*
From: Familial breast cancer: characteristics and outcome of BRCA 1–2 positive and negative cases
CHARACTERISTICS OF PATIENTS | BRCA-WT (n = 86) | BRCA+ (n = 29) | p-value# | Hazard Ratio (95% CI) |
|---|---|---|---|---|
Average age in years (range) | 45.3 (22–82) | 42.3 (26–62) | _ | _ |
Laterality (right/left/bilat)+ | 35/41/5 | 15/13/1 | 0.68 | 1.3 (0.1–5.7) |
Premenopausal | 53/81 (65%) | 23/29 (79%) | 0.17 | 1.9 (0.5–6.7) |
T3-T4 | 8/83 (10%) | 3/23 (13%) | 0.64 | 1.2 (0.3–6.5) |
N+ | 37/76 (49%) | 17/27 (63%) | 0.20 | 1.4 (0.5–4.6) |
G3 | 31/77 (40%) | 19/25 (76%) | 0.002 | 2.6 (0.8–7.2) |
Multifocal-multicentric | 38/82 (46%) | 8/24 (33%) | 0.26 | 0.8 (0.1–3.7) |
ER- | 20/70 (29%) | 10/23 (43%) | 0.18 | 1.5 (0.4–5.1) |
Pgr- | 22/72 (31%) | 8/23 (35%) | 0.71 | 1.1 (0.2–6.7) |
HER2 2+/3+ | 11/31 (35%) | 2/13 (15%) | 0.18 | 0.6 (0.02–4.9) |