Table 2 Age adjusted odds ratios by p53 status relative to polyp-free controls.
From: Tobacco, alcohol, and p53 overexpression in early colorectal neoplasia
No p53 protein overexpression | p53 protein overexpression | |
|---|---|---|
Cigarette Smoking | ||
Never | 1.0 | 1.0 |
Former | 1.3 (0.8–2.1) | 1.1 (0.5–2.5) |
Current | 1.7 (0.9–3.2) | 1.6 (0.5–4.8) |
Total number of years smoking* | ||
< 15 years | 1.4 (0.7–2.7) | 2.2 (0.8–6.4) |
15 – 29 years | 0.9 (0.5–1.7) | 0.9 (0.3–2.7) |
30+ years | 1.8 (1.1–2.9) | 1.1 (0.4–2.8) |
Pipes or cigars | ||
Never | 1.0 | 1.0 |
Ever | 1.0 (0.5–1.7) | 1.6 (0.7–3.9) |
Alcohol | ||
Nondrinkers | 1.0 | 1.0 |
Beer 1–7 bottles/week | 1.6 (0.9–2.6) | 0.4 (0.1–1.9) |
Beer 8+ bottles/week | 2.2 (1.0–4.7) | 4.5 (1.6–12.4) |
Wine (any wine during week) | 1.2 (0.8–1.8) | 0.8 (0.4–1.8) |
Liquor (any liquor during week) | 1.2 (0.8–1.8) | 1.0 (1.0–4.2) |
Total alcohol (wine+beer+liquor) | ||
1–13 drinks/week | 1.1 (0.7–1.8) | 0.8 (0.3–2.1) |
14+ drinks/week | 1.5 (0.9–2.6) | 2.4 (1.0–5.7) |
Body Size and Physical Activity | ||
Body mass index (kg/m2) | ||
< 22.5 | 1.0 | 1.0 |
22.5 – <25.5 | 1.1 (0.8–2.3) | 1.2 (0.5–3.7) |
25.5+ | 2.0 (1.2–3.3) | 1.7 (0.7–4.3) |
Leisure physical activity | ||
None | 1.0 | 1.0 |
2–4 hours/week | 0.5 (0.2–1.4) | 0.5 (0.1–3.5) |
5+ hours/week | 0.8 (0.4–1.6) | 1.3 (0.5–3.7) |
Dietary variables | ||
Fiber: < 12.5 grams/day | 1.0 | 1.0 |
12.5 – <17 grams/day | 0.9 (0.5–1.5) | 0.3 (0.1–1.1) |
17+ grams/day | 1.1 (0.7–1.9) | 0.9 (0.4–2.2) |
Fat: < 60 grams/day | 1.0 | 1.0 |
60 – <85.5 grams/day | 0.7 (0.4–1.2) | 1.6 (0.6–3.9) |
85.5 grams/day | 1.1 (0.7–1.8) | 1.2 (0.5–3.3) |