Table 4 Risk of lung cancer in association with aspirin use among current and former smokers – Effect of packyears of cigarettes smoked – Roswell Park Cancer Institute, 1982–1998.
Lower tertile of packyear distribution (1 – 34 packyears) | Middle tertile of packyear distribution (34.1 – 60 packyears) | Upper tertile of packyear distribution (60.1 – 260 packyears) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Cases (n = 162) | Controls (n = 288) | Adjusted OR1 (95% CI) | Cases (n = 307) | Controls (n = 157) | Adjusted OR1 (95% CI) | Cases (n = 336) | Controls (n = 90) | Adjusted OR1 (95% CI) | |
Non-User | 149 | 238 | 1.0 | 264 | 127 | 1.0 | 278 | 68 | 1.0 |
Regular User2 | 13 | 50 | 0.43 (0.22–0.83) | 43 | 30 | 0.70 (0.41–1.18) | 58 | 22 | 0.66 (0.37–1.16) |
1–6 tablets/week | 2 | 10 | 0.32 (0.07–1.53) | 7 | 5 | 0.62 (0.19–2.05) | 16 | 2 | 2.02 (0.45–9.04) |
7+ tablets/week | 11 | 40 | 0.45 (0.22–0.92) | 36 | 25 | 0.71 (0.40–1.26) | 42 | 20 | 0.52 (0.28–0.95) |
p = 0.02 | p = 0.20 | p = 0.06 | |||||||
1–10 years of use | 10 | 35 | 0.47 (0.22–0.99) | 33 | 23 | 0.66 (0.37–1.19) | 44 | 16 | 0.68 (0.36–1.29) |
11+ years of use | 3 | 15 | 0.32 (0.09–1.16) | 10 | 7 | 0.83 (0.30–2.29) | 14 | 6 | 0.59 (0.22–1.61) |
p = 0.01 | p = 0.26 | p = 0.15 | |||||||
1–10 tablet years3 | 10 | 27 | 0.60 (0.28–1.30) | 33 | 22 | 0.70 (0.38–1.26) | 38 | 12 | 0.78 (0.38–1.58) |
11+ tablet years | 3 | 23 | 0.22 (0.06–0.75) | 10 | 8 | 0.70 (0.26–1.86) | 20 | 10 | 0.51 (0.22–1.15) |
p = 0.006 | p = 0.21 | p = 0.09 | |||||||